Smoking, female gender and PI use are associated with decreasing renal function in TDF-containing HAART

نویسندگان

  • A Uglietti
  • C Gervasoni
  • E Gabrielli
  • S Di Giambenedetto
  • R Cauda
  • R Esposito
  • P Grima
  • G Di Perri
  • R Maserati
  • M Galli
چکیده

Methods OSMA-1 (Observational Study on Metabolic Abnormalities), a multicenter Italian study, was designed to evaluate since February 2008 the efficacy and the safety of TDF-based regimen in a real-life clinical setting. HIV infected, therapy naïve subjects were enrolled. GFR was estimated using Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Statistical analyses used a parametric test and a mixed model was used to analysis changes from baseline to 6, 12, and 24 months, with the different variables as fixed effect plus visit (categorical) and baseline value (continuous as covariate).

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عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2010